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Article

Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis.

Cardiovascular diabetology - 12 May 2025

Lin Mingzhi, Guo Jiuqi, Tao Hongqian, Gu Zhilin, Tang Wenyi, Zhou Fuliang, Jiang Yanling, Zhang Ruyi, Jia Dalin, Sun Yingxian, Jia Pengyu

Abstract excerpt

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent clinical syndrome with high morbidity and mortality. Although HFpEF frequently coexists with cardiometabolic diseases, the causal mechanisms and potential mediators remain poorly understood. OBJECTIVES: This study aimed to identify cardiometabolic risk factors specifically driving HFpEF and to determine their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40355922
DOI: 10.1186/s12933-025-02738-0
PMCID: PMC12070650

Genes

IL1R1
FGF19
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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