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Article

The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence.

Open biology - 1 Sept 2017

Wang Ke, Chen Yi-Qiang, Salido May M, Kohli Gurjeet S, Kong Jin-Liang, Liang Hong-Jie, Yao Zi-Ting, Xie Yan-Tong, Wu Hua-Yu, Cai Shuang-Qi, Drautz-Moses Daniela I, Darling Aaron E, Schuster Stephan C, Yang Liang, Ding Yichen

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen that causes severe airway infections in humans. These infections are usually difficult to treat and associated with high mortality rates. While colonizing the human airways, P. aeruginosa could accumulate genetic mutations that often lead to its better adaptability to the host environment. Understanding these evolutionary traits may provide important clues for...

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PMID: 28878043
DOI: 10.1098/rsob.170029
PMCID: PMC5627047

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