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A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved <i>Pseudomonas aeruginosa</i> predict those in naturally evolved bacteria

2019-06-18

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections. An increasing number of isolates have acquired mutations that make them antibiotic resistant, making treatment more difficult. To identify resistance-associated mutations we experimentally evolved the antibiotic sensitive strain P. aeruginosa PAO1 to become resistant to three widely used anti-pseudomonal...

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Literature Corpus work
a7d7ff30-3f39-5d6f-a0c8-048f480e9acd
DOI
10.1101/674531
Open publication

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A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved <i>Pseudomonas aeruginosa</i> predict those in naturally evolved bacteriaDOI 10.1101/674531
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