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Article

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa.

Microbiology spectrum - 1 Apr 2025

Yu Xiao-Quan, Yang Hao, Feng Han-Zhong, Hou Jun, Tian Jun-Qiang, Niu Shao-Min, You Chong-Ge, Tao Xuan-Yu, Zhang Si-Ping, Wang Zhi-Ping, He Yong-Xing

Abstract excerpt

Antibiotic resistance is emerging as a significant global health crisis, necessitating the urgent development of novel antibiotics or alternative therapies. Although it is recognized that bacteria require multiple mutations to develop resistance levels exceeding the mutant prevention concentration, the specific mutation combinations conferring high resistance have been largely undefined. Here, we investigated the...

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Identifiers

PMID: 39982069
DOI: 10.1128/spectrum.02981-24
PMCID: PMC11960432

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