Article

Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA

2023-11-30

Abstract excerpt

<title>Abstract</title> <p>Transplantation of stem cell-derived β-cells is a promising therapeutic advancement in the treatment of type 1 diabetes mellitus. A current limitation of this approach is the long differentiation timeline of up to two months that generates a heterogeneous population of pancreatic endocrine cells. To address this limitation, an inducible lentiviral overexpression system of mature β-cell...

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Literature Corpus work: 37ce3b92-2833-5718-b194-1fb056721473
DOI: 10.21203/rs.3.rs-3658114/v1

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