Article

Novel MAFA+, ISL1+, NKX6-1-stem cell derived pancreatic cell clusters secrete insulin and control blood glucose in rodent models of diabetes

2023-10-23

Abstract excerpt

This article describes a stem cell line derived by reprogramming of native human islet cells that consistently generates pure populations of endocrine pancreatic clusters following a simple differentiation protocol. Surprisingly, the population of stem cell derived pancreatic endocrine clusters that was most consistently capable of regulating blood glucose in rodent models of diabetes lacked robust expression of t...

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Literature Corpus work: a7f65e85-77bb-5e11-a1c2-fec9bb5a7b93
DOI: 10.1101/2023.10.20.563345

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