Article

Direct Differentiation of Human Pancreatic Islet-Derived Mesenchymal Stromal Cells into Glucose-Responsive Insulin-Producing Cells

2026-07-16

Abstract excerpt

<title>Abstract</title> <p>Background Type 1 diabetes mellitus affects millions of people worldwide, with β-cell replacement representing a final therapeutic goal. Direct lineage reprogramming offers a promising alternative to pluripotent stem cell–based approaches, bypassing the need for complex stepwise differentiation. Mesenchymal stromal cells derived from human pancreatic islets (hPD-MSCs) retain a pancreat...

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Literature Corpus work: c576d8fc-c74d-5c41-b8fd-d3e9b5fd3dd0
DOI: 10.21203/rs.3.rs-9705786/v1

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