Article

TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> The formation of a single central lumen is a critical step for glandular morphogenesis. Patients with loss of function variants in the chaperone protein TTC7A have multiple lumen formation in colonic crypt glands. We show that trafficking and localization of TTC7A to the plasma membrane is required for directionally specifying the apical membrane with TTC7A patient loss-of-function variants lead...

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Literature Corpus work: 37bb9af9-5d96-5297-898d-b93dc8ac58b5
DOI: 10.1101/2025.03.22.644724

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