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Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease

1 Feb 2018

Abstract excerpt

The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of nutrients. The establishment of cell polarity requires a specialized subcellular machinery to transport and recycle proteins to their appropriate location. In order to...

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PMID: 29590640
DOI: 10.1242/dmm.031088

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