Article

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signalling to promote expansion of cortical progenitors

2020-06-18

Abstract excerpt

<h4>Summary</h4> The primary cilum is a central component of signalling during neural development, from regional patterning to neuronal differentiation. Here we focus on CROCCP2, a hominid-specific gene duplicate from CROCC (Ciliary Rootlet Coiled Coil), also known as rootletin, that encodes the major protein component of the ciliary rootlet. We find that CROCCP2 is highly expressed in the human fetal brain and n...

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Literature Corpus work: 4ff3f2a7-8214-5f72-807e-d1a23fed6cb7
DOI: 10.1101/2020.06.17.142976

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