Article

Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in trachea-esophageal morphogenesis

2023-10-11

Abstract excerpt

<h4>Summary</h4> Disruptions in foregut morphogenesis can result in life-threatening conditions where the trachea and esophagus fail to separate properly, such as esophageal atresia (EA) and tracheoesophageal fistulas (TEF). The developmental basis of these congenital anomalies is poorly understood, but recent genome sequencing reveals that de novo variants in intracellular trafficking genes are enriched in EA/T...

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Literature Corpus work: a9c86840-39a3-5abd-8fc9-4285dab785ea
DOI: 10.1101/2023.10.11.561909

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