Article

Primary Cilia are WNT Transducing Organelles whose Biogenesis is Regulated by a WNT┫ PP1 axis

2022-12-10

Abstract excerpt

<h4>SUMMARY</h4> WNT signalling is of paramount importance in development, stem cell maintenance, and disease. WNT ligands typically signal via receptor activation at the plasma membrane to induce β-catenin-dependent gene activation. Here we show that in primary cilia, WNT receptors relay a WNT/GSK3 signal that β-catenin-independently promotes ciliogenesis. Innovations supporting this conclusion are monitoring ac...

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Literature Corpus work: 929232cf-98a5-5e83-b7d2-81f07a300d47
DOI: 10.1101/2022.12.09.519813

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