Article

Elevated neuronal TAF15 expression leads to FTD-like phenotype

2025-12-16

Abstract excerpt

<h4>Summary</h4> TAF15, a DNA/RNA-binding protein whose dysfunction in alternative splicing impairs NMDA receptor signaling, can form amyloid fibrils that contribute to neurodegeneration in the neurodegenerative diseases like FTD and ALS, indicating a close involvement of TAF15 in both neuronal physiological function and activation of pathological pathways. However, the relationship between TAF15 expression level...

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Literature Corpus work: 37b93c11-1aab-5163-a070-9c2d8c5d9062
DOI: 10.64898/2025.12.13.694105

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