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Article

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

16 Oct 2014

Abstract excerpt

The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and pathological features. Both missense mutations and overexpression of wild-type FUS protein can be pathogenic in human patients. To study the molecular and cellular basis by which FUS mutations and...

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PMID: 25324524
DOI: 10.1073/pnas.1406162111

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