Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.

doi:10.1038/ncomms12143

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Article

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.

Nature communications - 5 Jul 2016

Kapeli Katannya, Pratt Gabriel A, Vu Anthony Q, Hutt Kasey R, Martinez Fernando J, Sundararaman Balaji, Batra Ranjan, Freese Peter, Lambert Nicole J, Huelga Stephanie C, Chun Seung J, Liang Tiffany Y, Chang Jeremy, Donohue John P, Shiue Lily, Zhang Jiayu, Zhu Haining, Cambi Franca, Kasarskis Edward, Hoon Shawn, Ares Manuel, Burge Christopher B, Ravits John, Rigo Frank, Yeo Gene W

Abstract excerpt

The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mouse brains. TAF15 and FUS exhibit similar binding patterns in introns, are enriched in 3' untranslated regions and...

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PMID: 27378374
DOI: 10.1038/ncomms12143
PMCID: PMC4935974

Genes

TAF15
FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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