Article
Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
The EMBO journal - 2 Oct 2017
Agís-Balboa Roberto Carlos, Pinheiro Paulo S, Rebola Nelson, Kerimoglu Cemil, Benito Eva, Gertig Michael, Bahari-Javan Sanaz, Jain Gaurav, Burkhardt Susanne, Delalle Ivana, Jatzko Alexander, Dettenhofer Markus, Zunszain Patricia A, Schmitt Andrea, Falkai Peter, Pape Julius C, Binder Elisabeth B, Mulle Christophe, Fischer Andre, Sananbenesi Farahnaz
Abstract excerpt
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated...
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