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Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

3 Jan 2019

Abstract excerpt

Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration. Here we found that, in the late-stage familial Alzheimer's disease (FAD) mouse model, repressive histone H3 dimethylation at lysine 9 (H3K9me2) and euchromatic histone methyltransferases EHMT1 and EHMT2 were significantly elevated in the...

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PMID: 30668640
DOI: 10.1093/brain/awy354

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