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Article

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.

Acta neuropathologica communications - 16 Nov 2023

Pelaez Mari Carmen, Desmeules Antoine, Gelon Pauline A, Glasson Bastien, Marcadet Laetitia, Rodgers Alicia, Phaneuf Daniel, Pozzi Silvia, Dutchak Paul A, Julien Jean-Pierre, Sephton Chantelle F

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases that belong to a common disease spectrum based on overlapping clinical, pathological and genetic evidence. Early pathological changes to the morphology and synapses of affected neuron populations in ALS/FTD suggest a common underlying mechanism of disease that requires further investigation. Fused in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37974279
DOI: 10.1186/s40478-023-01671-1
PMCID: PMC10652582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.PMID 37974279Read ↗

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