Article

Gata4 drives Hh-signaling for second heart field migration and outflow tract development

2018-09-25

Abstract excerpt

Dominant mutations of Gata4, an essential cardiogenic transcription factor (TF), cause outflow tract (OFT) defects in both human and mouse. We investigated the molecular mechanism underlying this requirement. Gata4 happloinsufficiency in mice caused OFT defects including double outlet right ventricle (DORV) and conal ventricular septum defects (VSDs). We found that Gata4 is required within Hedgehog (Hh)-receiving...

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Literature Corpus work: 37adc3f0-f5a0-5e24-8f6b-03f1fd173c29
DOI: 10.1101/427336

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