Article
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.
Molecular neurodegeneration - 18 May 2024
Winfree Rebecca L, Nolan Emma, Dumitrescu Logan, Blennow Kaj, Zetterberg Henrik, Gifford Katherine A, Pechman Kimberly R, Seto Mabel, Petyuk Vladislav A, Wang Yanling, Schneider Julie, Bennett David A, Jefferson Angela L, Hohman Timothy J
Abstract excerpt
Recent evidence suggests that Alzheimer's disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele of the protective variant (rs1582763) is associated with higher sTREM2 and lower AD risk while the minor allele of (rs6591561) relates to lower sTREM2 and higher AD risk. Our group previously found that...
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