Article

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

2021-10-16

Abstract excerpt

The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here, we present a spatial proteogenomic atlas of the healthy human and murine liver combining single-cell CITE-seq, single-nuclei sequencing, spatial transcriptomics and spatial proteomics. By integrating these multi-omic datasets, we provide validated strategies to reliably discriminate and localize all hepatic cells. We...

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Literature Corpus work: 2402ed83-e100-59f0-a534-04380d6c9659
DOI: 10.1101/2021.10.15.464432

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