Article

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

2019-09-12

Abstract excerpt

Currently there are no effective antifibrotic therapies for liver cirrhosis, a major killer worldwide. To obtain a cellular resolution of directly-relevant pathogenesis and to inform therapeutic design, we profile the transcriptomes of over 100,000 primary human single cells, yielding molecular definitions for the major non-parenchymal cell types present in healthy and cirrhotic human liver. We uncover a novel sca...

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Literature Corpus work: ae56fac0-a5ed-5b91-bc07-f649297fce2c
DOI: 10.1101/766113

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