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Integrated genetic profiling of archival pediatric high-grade glial tumors and reassessment with 2021 WHO classification of paediatric CNS tumours.

Cancer genetics - 1 Jun 2023

Cooley Linda D, Lansdon Lisa A, Laurence Kris, Herriges John C, Zhang Lei, Repnikova Elena A, Joyce Julie, Thakor Preeti, Warren Lisa, Smith Scott C, Yoo Byunggil, Gener Melissa, Ginn Kevin F, Farooqi Midhat S

Abstract excerpt

Though rare, pediatric high-grade gliomas (pHGG) are a leading cause of cancer-related mortality in children. We wanted to determine whether our currently available clinical laboratory methods could better define diagnosis for pHGG that had been archived at our institution for the past 20 years (1998 to 2017). We investigated 33 formalin-fixed paraffin-embedded pHGG using ThermoFisher Oncoscan SNP microarray with...

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Brain Neoplasms
Central Nervous System Neoplasms
Child
Glioma
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

World Health Organization

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PMID: 36917897
DOI: 10.1016/j.cancergen.2023.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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