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Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

21 Dec 2021

Abstract excerpt

mRNA vaccines for SARS-CoV-2 have shown exceptional clinical efficacy, providing robust protection against severe disease. However, our understanding of transcriptional and repertoire changes following full vaccination remains incomplete. We used scRNA-Seq and functional assays to compare humoral and cellular responses to 2 doses of mRNA vaccine with responses observed in convalescent individuals with...

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Immunotherapy and Immune Responses
SARS-CoV-2 and COVID-19 Research
T-cell and B-cell Immunology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34935643
DOI: 10.1172/jci.insight.153201

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