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Article

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

17 Mar 2019

Abstract excerpt

Accumulating evidence demonstrates that CD8+ T cells contribute to protection from severe dengue virus (DENV) disease and vaccine efficacy. Nevertheless, molecular programs associated with DENV-specific CD8+ T cell subsets have not been defined. Here, we studied the transcriptomic profiles of human DENV-specific CD8+ T cells isolated after stimulation with DENV epitopes from donors who had been infected with DENV...

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PMID: 30882366
DOI: 10.1172/jci123726

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