Article

PCSK5 <sup>M452I</sup> is a recessive hypomorph exclusive to MCF10DCIS.com cells

2025-03-07

Abstract excerpt

<h4>ABSTRACT</h4> The most widely used cell line for studying ductal carcinoma in situ (DCIS) premalignancy is the transformed breast epithelial cell line, MCF10DCIS.com . During its original clonal isolation and selection, MCF10DCIS.com acquired a heterozygous M452I mutation in the proprotein convertase PCSK5, which has never been reported in any human cancer. The mutation is noteworthy because PCSK5 matures G...

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Literature Corpus work: 3712b12f-cc8c-59a4-ae88-d61c757b0d0e
DOI: 10.1101/2025.03.03.641323

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