Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PCSK5M452I Is a Recessive Hypomorph Exclusive to MCF10DCIS.com Cells.

Molecular cancer research : MCR - 6 Feb 2026

Marohl Taylor, Atkins Kristen A, Wang Lixin, Janes Kevin A

Abstract excerpt

The most widely used cell line for studying ductal carcinoma in situ (DCIS) premalignancy is the transformed breast epithelial cell line, MCF10DCIS.com. During its original clonal isolation and selection, MCF10DCIS.com acquired a heterozygous M452I mutation in the proprotein convertase PCSK5, which has never been reported in any human cancer. The mutation is noteworthy because PCSK5 matures GDF11, a TGFβ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Carcinoma, Intraductal, Noninfiltrating
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41148168
DOI: 10.1158/1541-7786.MCR-25-0211
PMCID: PMC12671455

Genes

PCSK5
GDF11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

PCSK5M452I Is a Recessive Hypomorph Exclusive to MCF10DCIS.com Cells.PMID 41148168Read ↗

PCSK5 <sup>M452I</sup> is a recessive hypomorph exclusive to MCF10DCIS.com cellsSemantic proximity Read ↗

Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.Semantic proximity Read ↗

SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanismSemantic proximity Read ↗

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progressionSemantic proximity Read ↗

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast DevelopmentSemantic proximity Read ↗

PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.Semantic proximity Read ↗

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway RewiringSemantic proximity Read ↗

Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.Semantic proximity Read ↗

Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy.Semantic proximity Read ↗

Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.