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Article

Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.

Developmental cell - 20 Nov 2017

Bajikar Sameer S, Wang Chun-Chao, Borten Michael A, Pereira Elizabeth J, Atkins Kristen A, Janes Kevin A

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous carcinoma in which various tumor-suppressor genes are lost by mutation, deletion, or silencing. Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechanism of its inactivation in TNBC. GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and...

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Source

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Identifiers

PMID: 29161592
DOI: 10.1016/j.devcel.2017.10.027
PMCID: PMC5726799

Genes

GDF11
PCSK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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