Article

SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanism

2025-01-20

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor of invasive ductal carcinoma (IDC). The challenge lies in discriminating between DCIS progressors and DCIS non-progressors, often resulting in over- or under-treatment in many cases. Membrane type 1 (MT1)-matrix metalloproteinase (MMP) has been previously identified as an essential gene involved in DCIS progression. Here, RN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8cea131-af41-53f0-9e83-a27d09f3e83e
DOI: 10.1101/2025.01.17.632337

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanismDOI 10.1101/2025.01.17.632337Read

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progressionSemantic proximity Read

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma <i>In Situ</i> to Invasive Breast CancerSemantic proximity Read

Progression-specific genes identified in microdissected formalin-fixed and paraffin-embedded tissue containing matched ductal carcinoma in situ and invasive ductal breast cancersSemantic proximity Read

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasisSemantic proximity Read

Identifying progression predictors of breast ductal carcinoma in situSemantic proximity Read

Tumor microenvironmental determinants of high-risk DCIS progressionSemantic proximity Read

Tumor microenvironmental determinants of high-risk DCIS progressionSemantic proximity Read

A pan-cancer analysis of matrisome proteins reveals CTHRC1and LOXL2 as major ECM regulators across cancersSemantic proximity Read

A Molecular Portrait of High-Grade Ductal Carcinoma In Situ.Semantic proximity Read

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like CarcinomasSemantic proximity Read

MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 proteinSemantic proximity Read

Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell ActivitySemantic proximity Read