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Article

PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.

FEBS letters - 1 Feb 2022

Jakubik Charles T, Weckerly Claire C, Hammond Gerald R V, Bresnick Anne R, Backer Jonathan M

Abstract excerpt

PI3Kβ is required for invadopodia-mediated matrix degradation by breast cancer cells. Invadopodia maturation requires GPCR activation of PI3Kβ and its coupling to SHIP2 to produce PI(3,4)P2 . We now test whether selectivity for PI3Kβ is preserved under conditions of mutational increases in PI3K activity. In breast cancer cells where PI3Kβ is inhibited, short-chain diC8-PIP3 rescues gelatin degradation in a...

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Identifiers

PMID: 34990021
DOI: 10.1002/1873-3468.14273
PMCID: PMC8885911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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