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Article

Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator.

Scientific reports - 10 Jan 2018

Chen Yu-Chih, Humphries Brock, Brien Riley, Gibbons Anne E, Chen Yu-Ting, Qyli Tonela, Haley Henry R, Pirone Matthew E, Chiang Benjamin, Xiao Annie, Cheng Yu-Heng, Luan Yi, Zhang Zhixiong, Cong Jason, Luker Kathryn E, Luker Gary D, Yoon Euisik

Abstract excerpt

Isolation of tumor-initiating cells currently relies on markers that do not reflect essential biologic functions of these cells. We proposed to overcome this limitation by isolating tumor-initiating cells based on enhanced migration, a function tightly linked to tumor-initiating potential through epithelial-to-mesenchymal transition (EMT). We developed a high-throughput microfluidic migration platform with...

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Identifiers

PMID: 29321615
DOI: 10.1038/s41598-017-18610-5
PMCID: PMC5762897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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