Article

Telomerase RNA regulates the epigenome primed for human lineage commitment

2026-07-03

Abstract excerpt

Telomerase RNA ( TERC ) is known as the essential template for telomere elongation. Here, we report an unexpected role for TERC in regulating chromatin accessibility, which is primed for determining the cell fate of human embryonic stem cells (hESCs). TERC -deficient hESCs retain critical markers for pluripotency but fail to undergo lineage differentiation as shown by standard in vivo teratoma formation as wel...

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Literature Corpus work: 36ffdadc-e3c3-5e0b-9aa0-61780bb26d93
DOI: 10.64898/2026.07.03.736284

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