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Article

Short Telomeres in ESCs Lead to Unstable Differentiation

1 Apr 2013

Abstract excerpt

Functional telomeres are critical for stem cell proliferation; however, whether they are equally important for the stability of stem cell differentiation is not known. We found that mouse embryonic stem cells (ESCs) with critically short telomeres (Tert(-/-) ESCs) initiated normal differentiation after leukemia inhibitory factor (LIF) withdrawal but, unlike control ESCs, failed to maintain stable differentiation...

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PMID: 23561444
DOI: 10.1016/j.stem.2013.01.018

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