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Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics

7 Jul 2019

Abstract excerpt

gene in most normal human somatic cells, whereas activated only in small subsets of cells, including stem cells, activated lymphocytes, and other highly proliferative cells. In contrast, telomerase activation via TERT induction is widespread in human malignant cells, which is a prerequisite for malignant transformation. It is well established that TERT/telomerase extends telomere length, thereby conferring...

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Share to DNA Repair Mechanisms
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PMID: 31284662
DOI: 10.3390/ijms20133338

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