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Article

Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.

Cell reports - 12 Jul 2016

Forloni Matteo, Gupta Romi, Nagarajan Arvindhan, Sun Li-Sha, Dong Yuying, Pirazzoli Valentina, Toki Maria, Wurtz Anna, Melnick Mary Ann, Kobayashi Susumu, Homer Robert J, Rimm David L, Gettinger Scott J, Politi Katerina, Dogra Shaillay Kumar, Wajapeyee Narendra

Abstract excerpt

Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of this silencing in oncogenesis are not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces silencing of multiple unrelated tumor suppressors in lung adenocarcinomas and glioblastomas by inhibiting the DNA...

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Identifiers

PMID: 27346347
DOI: 10.1016/j.celrep.2016.05.087
PMCID: PMC4945411

Genes

TET1
EGFR

Provenance

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