Article

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

2021-09-23

Abstract excerpt

Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). Despite their importance for tumor growth, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulator...

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Literature Corpus work: 27ddd658-e546-571e-8f06-e4c0bd8877c0
DOI: 10.1101/2021.09.20.461125

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