Article

BRD4/H3K27Ac Epigenetic Reprogramming Orchestrates Chemotherapy-induced Polyploid Giant Cancer Cells and Glioma Progression

2026-05-19

Abstract excerpt

<title>Abstract</title> <p> Glioma chemoresistance is a primary driver of disease recurrence and poor patient survival. In this study, we demonstrate for the first time that glioma resistance to temozolomide (TMZ) is directly linked to the formation of polyploid giant cancer cells (PGCCs), both <italic>in vivo</italic> and <italic>in vitro</italic> . The prevalence of PGCCs is progressively increased with gl...

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Literature Corpus work: f42f7d64-ad7a-50d3-9b28-93e2f0d424ee
DOI: 10.21203/rs.3.rs-9526893/v1

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