Article
Fatal correlation between YAP1 expression and glioma aggressiveness: clinical and molecular evidence.
The Journal of pathology - 1 Oct 2018
Guichet Pierre-Olivier, Masliantsev Konstantin, Tachon Gaëlle, Petropoulos Christos, Godet Julie, Larrieu Delphine, Milin Serge, Wager Michel, Karayan-Tapon Lucie
Abstract excerpt
During the last decade, large-scale genomic analyses have clarified the somatic alterations in gliomas, providing new molecular classification based on IDH1/2 mutations and 1p19q codeletion with more accurate patient prognostication. The Hippo pathway downstream effectors, YAP1 and TAZ, have recently emerged as major determinants of malignancy by inducing proliferation, chemoresistance, and metastasis in solid...
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