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Article

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2021

Vigneswaran Krishanthan, Boyd Nathaniel H, Oh Se-Yeong, Lallani Shoeb, Boucher Andrew, Neill Stewart G, Olson Jeffrey J, Read Renee D

Abstract excerpt

PURPOSE: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often driven by genetic aberrations in receptor tyrosine kinases, such as amplification and mutation of EGFR. EXPERIMENTAL DESIGN: Using a Drosophila glioma model and human...

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Identifiers

PMID: 33172899
DOI: 10.1158/1078-0432.CCR-20-0018
PMCID: PMC8440125

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