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A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development

3 Aug 2022

Abstract excerpt

Current therapies remain unsatisfactory in preventing the recurrence of glioblastoma multiforme (GBM), which leads to poor patient survival. By rational engineering of the transcription factor SOX2, a key promoter of GBM malignancy, together with the Kruppel-associated box and DNA methyltransferase3A/L catalytic domains, we generated a synthetic repressor named SOX2 epigenetic silencer (SES), which induces the...

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PMID: 35921410
DOI: 10.1126/sciadv.abn3986

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