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Article

Dynamics of ten‐eleven translocation hydroxylase family proteins and 5‐hydroxymethylcytosine in oligodendrocyte differentiation

25 Feb 2014

Abstract excerpt

The ten-eleven translocation (TET) family of methylcytosine dioxygenases catalyze oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA demethylation. Despite the abundance of 5hmC and TET proteins in the brain, little is known about their role in oligodendrocytes (OLs). Here, we analyzed TET expression during OL development in vivo and in vitro, and found that three TET family...

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PMID: 24615693
DOI: 10.1002/glia.22649

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