Article

Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects

2021-02-07

Abstract excerpt

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the Huntingtin gene ( HTT ). While HD has been shown to have a developmental component, how early during human embryogenesis the HTT-CAG expansion can cause embryonic defects remains unknown. Here, we demonstrate a specific and highly reproducible CAG length-dependent phenotypic signature in a synthetic mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36909ece-0158-5967-8b82-601438018aff
DOI: 10.1101/2021.02.06.430005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defectsDOI 10.1101/2021.02.06.430005Read

Early Neurodevelopmental Defects in Huntington’s Disease are Driven by Choroid Plexus Overgrowth and Altered Paracrine SignalingSemantic proximity Read

Chromosomal instability during neurogenesis in Huntington's disease.Semantic proximity Read

Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoidsSemantic proximity Read

Simplified In Vitro Generation of Human Gastruloids for Modelling Early DevelopmentSemantic proximity Read

Functions of huntingtin in germ layer specification and organogenesis.Semantic proximity Read

A robust, reproducible, accessible and scalable protocol for generating three-dimensional human gastruloidsSemantic proximity Read

Hypomorphic mutation of the mouse Huntington’s disease gene orthologueSemantic proximity Read

YAP levels regulate anteroposterior elongation of hESC-derived gastruloidsSemantic proximity Read

Disruption of Epithelial Integrity Drives Mesendoderm Differentiation in Human Induced Pluripotent Stem Cells by Enabling BMP and ACTIVIN SensingSemantic proximity Read

Chimeric 3D gastruloids - a versatile tool for studies of mammalian peri-gastrulation development.Semantic proximity Read

Notch signalling governs human enteric nervous system progenitor dynamicsSemantic proximity Read

HUNTINGTON DISEASE ALTERS THE PATTERNING OF NEOCORTICAL AREA IN MICESemantic proximity Read