Article

Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model

2025-04-20

Abstract excerpt

Familial Danish Dementia (FDD) is a rare autosomal dominant neurodegenerative disorder caused by a mutation in the integral membrane protein 2B ( ITM2b ) gene. Clinically, FDD is characterized by cerebral amyloid angiopathy (CAA), cerebellar ataxia, and dementia. Notably, FDD shares several neuropathological features with Alzheimer’s disease (AD), including CAA, neuroinflammation, and neurofibrillary tangles. In...

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Literature Corpus work: 36753bba-e663-5d0c-9220-31da00f24961
DOI: 10.1101/2025.04.15.649002

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