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Article

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2010

Tamayev Robert, Matsuda Shuji, Fà Mauro, Arancio Ottavio, D'Adamio Luciano

Abstract excerpt

According to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive alterations. To efficiently reproduce amyloid lesions, murine models of human dementias invariably use transgenic expression systems. However, recent FDD transgenic models showed...

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Identifiers

PMID: 21098268
DOI: 10.1073/pnas.1011689107
PMCID: PMC2996452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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