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Article

Neurological Phenotypes in Mouse Models of Mitochondrial Disease and Relevance to Human Neuropathology.

International journal of molecular sciences - 2 Jun 2023

Olkhova Elizaveta A, Smith Laura A, Bradshaw Carla, Gorman Gráinne S, Erskine Daniel, Ng Yi Shiau

Abstract excerpt

Mitochondrial diseases represent the most common inherited neurometabolic disorders, for which no effective therapy currently exists for most patients. The unmet clinical need requires a more comprehensive understanding of the disease mechanisms and the development of reliable and robust in vivo models that accurately recapitulate human disease. This review aims to summarise and discuss various mouse models...

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Source

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Identifiers

PMID: 37298649
DOI: 10.3390/ijms24119698
PMCID: PMC10254022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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