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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

12 Apr 2010

Abstract excerpt

Familial Danish dementia (FDD) is a progressive neurodegenerative disease with cerebral deposition of Dan-amyloid (ADan), neuroinflammation, and neurofibrillary tangles, hallmark characteristics remarkably similar to those in Alzheimer's disease (AD). We have generated transgenic (tg) mouse models of familial Danish dementia that exhibit the age-dependent deposition of ADan throughout the brain with associated...

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PMID: 20385796
DOI: 10.1073/pnas.1001056107

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