Article

Familial Danish dementia young Knock-in rats expressing humanized APP and human Aβ show impaired pre and postsynaptic glutamatergic transmission

2021-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Familial British and Danish dementia (FBD and FDD) are two neurodegenerative disorders caused by mutations in the Integral membrane protein 2B (ITM2b) . BRI2, the protein encoded by ITM2b , tunes excitatory synaptic transmission at both pre- and post-synaptic terminus. Too, BRI2 interacts with and modulates proteolytic processing of Amyloid-β precursor Protein (APP), whose mutations cause fami...

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Literature Corpus work: 3eac6ab4-4d06-5acd-ac72-2af47c207039
DOI: 10.1101/2021.06.24.449787

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