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Memory Deficits Due to Familial British Dementia<i>BRI2</i>Mutation Are Caused by Loss of<i>BRI2</i>Function Rather than Amyloidosis

3 Nov 2010

Abstract excerpt

Familial dementias, which include Alzheimer disease (AD), familial British dementia (FBD), and familial Danish dementia (FDD), are caused by dominantly inherited autosomal mutations and are characterized by the production of amyloidogenic peptides, neurofibrillary tangles (NFTs) and neurodegeneration (St George-Hyslop and Petit, 2005; Garringer et al., 2009). The prevailing pathogenic theory, the "amyloid cascade...

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PMID: 21048150
DOI: 10.1523/jneurosci.3917-10.2010

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