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Regional and cellular gene expression changes in human Huntington's disease brain

8 Feb 2006

Abstract excerpt

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome-wide scale, we compared mRNA profiles from 44 human HD brains with those from 36 unaffected controls using microarray analysis. Four brain regions were...

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PMID: 16467349
DOI: 10.1093/hmg/ddl013

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