Article

Cell-specific transcription dysregulation in human Huntington’s disease-positive developing striatum

2026-06-19

Abstract excerpt

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-repeat expansion in the HTT gene. Progressive loss of striatal projection neurons leads to cognitive, psychiatric, and motor impairments that typically manifest in midlife, despite the presence of the expansion from conception. Increasing evidence supports a neurodevelopmental component to HD; however, authentic human de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 394a3a83-74b2-5c0c-8b2c-8d08709d79ca
DOI: 10.64898/2026.06.19.733377

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-specific transcription dysregulation in human Huntington’s disease-positive developing striatumDOI 10.64898/2026.06.19.733377Read

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.Semantic proximity Read

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington diseaseSemantic proximity Read

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neuronsSemantic proximity Read

The Caudate Nucleus Undergoes Dramatic and Unique Transcriptional Changes in Human Prodromal Huntington’s Disease BrainSemantic proximity Read

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.Semantic proximity Read

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brainSemantic proximity Read

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington’s Disease and Possible Therapeutic AvenuesSemantic proximity Read

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.Semantic proximity Read

Striatal specificity of gene expression dysregulation in Huntington's diseaseSemantic proximity Read

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.Semantic proximity Read

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease.Semantic proximity Read